New PDF release: The Role of Oxygen Radicals in Cardiovascular Diseases: A

By Lars Ernster (auth.), A. L’Abbate, F. Ursini (eds.)

ISBN-10: 9400926979

ISBN-13: 9789400926974

ISBN-10: 9401077169

ISBN-13: 9789401077163

Growing experimental facts is beeing produced in help of the thesis that lipid pe,oxidation is a vital mediator of either vascular and myocardial tissue derangement. even if the function of the free-radical procedure in human cardiovascular pathology continues to be speculative, however the capability implications of this sort of approach in either pharmacological remedy and prevention of significant cardiovascular ailments, akin to myocardial infarction, cardiomyopathy and arrhythmias, justify the expanding curiosity of scientific cardiologists during this study sector. moreover, present-day scientific cardiology allows to breed in guy such experimental types as ischemia and reperfusion, e.g. in the course of percutaneous transluminal angioplasty, or even to achieve histological and histochemical entry to byoptic myocardial tissue. Upon above premises the belief of a multidisciplinary dialogue assembly was once conceived, aimed to confront scientific expectancies with got uncomplicated details, and to debate the validity of experimental versions within the mild of pathological and scientific findings in guy. To this function, a distinct team of specialists within the box of free-radicals, from world wide, used to be requested to make the subject available to medical cardiologists, with the first target of projecting effects and concepts in the direction of strength medical learn; this is often, in truth, the thing of the eu Concerted motion "Breakdown in Human version - Cardiovascular Diseases", within the body of which the assembly used to be held.

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Extra info for The Role of Oxygen Radicals in Cardiovascular Diseases: A Conference in the European Concerted Action on Breakdown in Human Adaptation — Cardiovascular Diseases, held in Asolo, Italy, 2–5 December 1986

Example text

M. L. Dormandy : Life Chern. Rep. 3, (1985) 45. 29. G. F. H. R. L. Dormandy : Free Radical Res. Comms. 1987, in press. 30. A. Iversen, P. L. Dormandy : Ann. Clin. Biochem. 22, (1985) 137. 31. R. S. R. C. O. Lundberg: Ind. Eng. Chern. 49 (1957) 1713. 32. S. Bergstrom: Ark. Kern. Mineral. Geol. 21A (1945) 1. 33. 1. Ivanov: J. Free Rad. BioI. Med. 1, 34. S. T. Smith 35. M. R. Clemens, H Einsele, H. D. Waller Clin. Chim. Acta. 145, (1985) 283. 36. E. Hughes and S. B. Tove : J. BioI. Chern. 255, 1802.

Successful refIow is often marked by the occurrence of ventricular arrhythmias. Since reperfusion-induced arrhythmias may represent a lethal event in otherwise viable tissue, there is a clear need to understand their mechanisms of origin and develop pharmacological means for their effective control. FACTORS INFLUENCING THE VULNERABILITY OF THE HEART TO REPERFUSION-INDUCED ARRHYTHMIAS THE DURATION OF THE PRECEDING PERIOD OF ISCHEMIA This is perhaps the most important determinant of the vulnerability of the heart to reperfusion-induced arrhythmias.

1984. Trapping of free-radicals prevents endotoxin shock. 1st Meeting of European Shock Society - Manchester, 8th Sept. , Porciani, S. , 1986a. Fluidity of mitochondrial and microsomal membranes in traumatic shock as studied by ESR. P. Novelli and F. Ursini (Editors), Oxygen free radicals in shock, Karger, Basel, pp. 46-52. , Lippi, R. , 1986b. Anti-shock action of phenyl-t-butyl-nitrone, a spin trapper. P. Novelli and F. Ursini (Editors), Oxygen free radicals in shock, Karger, Basel, pp. 119-124.

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The Role of Oxygen Radicals in Cardiovascular Diseases: A Conference in the European Concerted Action on Breakdown in Human Adaptation — Cardiovascular Diseases, held in Asolo, Italy, 2–5 December 1986 by Lars Ernster (auth.), A. L’Abbate, F. Ursini (eds.)


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