By Alois Čihák PhD, Werner Reutter MD (auth.)
This quantity experiences a chain of other guides facing orotic acid. Orotic acid was once remoted from cow's milk seventy five years in the past via Biscaro and Belloni in Italy. Fifty years later back Italian scientists defined the growth-promoting task of orotic acid in diet B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides that are thinking about many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of those pyrimidines is definitely regulated. Disturbance of the biosynthetic pathway or trapping of person pyrimidine nucleotides could lead to critical metabolic and structural adjustments of cells. Synthesis, biochemical elements and physiological function are reviewed in 9 chapters. within the final twenty years expanding curiosity in orotic acid got here from numerous reviews displaying protecting or healing or precious results of this compound in several types of organ accidents: a variety of sorts of hepatic insufficiency, myocardial infarction, encephalopathy, memorization professional cesses, pointed out in Chapters eight and nine. on the finish of this evaluation a Bibliography in an alphabetical order with 673 references can provide additional perception during this topic.
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Etude clinique l'orotate d'AICA dans les hepatites et les cirrhoses. Acta Gastro-Enterol. , 32, 383-395 (1969) C18 Charbonnier, A. and Sagon, 1. Decouverte et etude experimentale des proprietes choIeretiques de l'acide uracyl-6carboxylique. Acta Gastro-Enterol. , 27, 295-311 (1964) C19 Cheeke, P. R. Effects of orotic acid on the development of vitamin E deficiency in rats. Can. 1. Anim. , 53,165-167 (1973) C20 Chelbova, K. , Golovinsky, E. V. and Hadjiolov, A. A. The action of some orotic acid analogues on the in vitro incorporation of [14C]-orotate into pyrimidine nucleotides.
Negishi, I. and Aizawa, Y. lap. I. , 25,345 (1975) 337. Novikoff, P. M. and Edelstein, D. Lab. , 36,215 (1977) 338. Sabesin, S. , Frase, S. and Ragland, J. B. Lab. , 37, 127 (1977) 339. , Adams, W. R. and Handschumacher, R. E. I. Cell. , 41, 625 (1969) 34 8. Physiological Effects Increasing experimental evidence indicates an important role of orotic acid in various cellular processes taking place in different types of cells and organisms. Orotic acid has been shown to stimulate the phagocytic activity of leukocytes [340-342] and of the reticuloendothelial system  by a process which can be abolished by pretreatment with hydrocortisone.
Soc. Exp. Bioi. , 125, 1251 (1967) 319. Porta, E. , Monning, C. and Hartroft, N. S. Arch. , 86,217 (1968) 320. Simon, J. , Scheig, R. and Klatskin, G. Proc. Soc. Exp. Bioi. , 129, 874 (1968) 321. Klain, G. , Sullivan, F. J. and Meikle, A. W. J. , 100, 1431 (1970) 322. , Storch, H. and Hohlfeld, R. Z. Ges. Inn. Med. , 25, 697 (1970) 323. Vaishwanar, I. and Jiddewar, G. G. IndianJ. , 7,214 (1970) 324. Torrielli, M. , Dianzani, M. U. and Ugazio, G. , 10,99 (1971) 33 OROTIC ACID 325. Pottenger, L. A.
Orotic Acid by Alois Čihák PhD, Werner Reutter MD (auth.)