By Michelle L. Gumz
This ebook sheds new gentle at the molecular mechanisms that generate circadian rhythms. It examines how organic rhythms impact physiological procedures similar to sleep, hormone synthesis and secretion, immunity, kidney functionality, the cardiovascular process, blood strain, and the digestive procedure. scientific implications are thought of whereas exploring the impression of rhythms on neuropsychiatric issues and chronotherapy’s capability for decreasing cardiovascular threat. providing a cross-section of craftsmanship in either uncomplicated and translational (bench-to-bedside) learn, this publication serves as a advisor for physicians and scientists who desire to study extra in regards to the impression of circadian rhythms on physiological methods in overall healthiness and ailment.
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Extra resources for Circadian Clocks: Role in Health and Disease
Negative feedback by the PER-containing complexes inhibits SETX activity, retarding release of RNA polymerase II from Per and Cry pre-mRNAs present within the complexes. Thus, the PER-containing complex recruits proteins that interfere with transcriptional re-initiation. RNA methylation performed by the RNA-binding protein Mettl3 influences transcript processing and inhibition of this enzyme lengthens circadian period (Fustin et al. 2013). In flies, products of the twenty-four (tyf) and ataxin-2 genes regulate circadian cycle length by affecting PER protein translation (Lim et al.
3 Histone Methylation In the Dbp gene, circadian rhythms of H3K9 acetylation and dimethylation peak in opposite phases, with the peak in acetylation occurring coincident with transcription and the peak of dimethylation occurring during the repression phase of the circadian cycle (Ripperger and Schibler 2006). Duong and Weitz (2014) recently reported that mouse PER protein complexes include a histone methyltransferase activity from the proteins HP1γ-Suv39h1-2 (suppressor of variegation 3–9 homolog 1 and 2).
1523/JNEUROSCI. 2013 Annayev Y, Adar S, Chiou Y-Y et al (2014) Gene Model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem 289:5013–5024. 534651 Antoch MP, Song EJ, Chang AM et al (1997) Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89:655–667 Antunes LC, Levandovski R, Dantas G et al (2010) Obesity and shift work: chronobiological aspects. Nutr Res Rev 23:155–168. 1017/S0954422410000016 Arble DM, Bass J, Laposky AD et al (2009) Circadian timing of food intake contributes to weight gain.
Circadian Clocks: Role in Health and Disease by Michelle L. Gumz