Download e-book for iPad: Cerebral Cortex: Neurodegenerative and Age-Related Changes by Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John

By Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John H. Morrison (eds.)

ISBN-10: 146137216X

ISBN-13: 9781461372165

ISBN-10: 1461548853

ISBN-13: 9781461548850

This quantity of Cerebral Cortex is devoted to Sir John Eccles, who was once an energetic member of the advisory board for the sequence until eventually his dying in might 1997. His enter as to what subject matters may be coated in destiny volumes of this sequence may be sorely ignored. the current quantity is anxious with neurodegenerative issues and age­ comparable alterations within the constitution and serve as of the cerebral cortex, an issue that has attracted expanding curiosity as durability and the variety of elderly members within the inhabitants elevate. even supposing a lot of the examine at the neurodegenerative results of getting older has been established on Alzheimer's sickness, lots of the getting older popu­ lation aren't stricken via this ailment. they are going to, besides the fact that, be laid low with the implications of ordinary getting older, so the 1st few chapters of this quantity are con­ cerned with that subject. bankruptcy 1, via Marilyn S. Albert and Mark B. Moss, offers an account of the cognitive adjustments that accompany general human getting older. bankruptcy 2, via Mark B.

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G. ), Lawrence Erlbaum, Newjersey, pp. 531-556. , 1987, Age differences in recognition memory of the rhesus monkey (Macaca mulatta), Neurobiol. Aging 8:435440. 41:204-213. , 1990, Visual discrimination and reversal learning in the aged monkey (Macaca mulatta), Behav. Neurosci. 104:876-888. , 1989, Evidence for task-

1994, Dopamine D2 receptor mechanisms in the cognitive performance of young adult and aged monkeys, Psychopharmacology (Berlin) 116:143-151. , 1989, Mnemonic and neuropathological effects of occluding the posterior cerebral artery in Macaca mulatta, Neuropsychologia 27:83-105. , 1991, Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction, Neurobiol. Aging 12:99-111. , 1992, Working memory, Science 255:556-559. , 1988, Aging and physiology of spatial memory, NeurobioL Aging 9:663-668.

Chan-Palay and Asan, 1989; Rosene, 1993). For example, in humans and monkeys there is an approximately 50% neuronal loss with age in the basal forebrain and a 35-40% loss in the locus coeruleus and dorsal raphe (Kemper, 1993). This compares with an approximate loss of 5% in CAl of the hippocampus. , 1977). , 1994). Changes in dopamine levels may also cause age-related changes in cognitive flexibility. , 1987). , 1994), making it possible to study this hypothesis in nonhuman primates. Moreover, although neuronal loss appears minimal in the hippocampus with age, recent reports suggest that molecular changes within the memory circuits are likely to contribute to performance declines in memory with advancing age.

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Cerebral Cortex: Neurodegenerative and Age-Related Changes in Structure and Function of Cerebral Cortex by Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John H. Morrison (eds.)


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