Download e-book for iPad: Cell Therapy for Lung Disease by Julia Polak

By Julia Polak

ISBN-10: 1848164394

ISBN-13: 9781848164390

Using stem cells to assist with lung regeneration and service is a singular treatment that could aid part out the necessity for traditional surgical or pharmacological techniques presently hired to regard ailments of the lung or different organs. the current e-book explores all avenues of this new type of therapy, relocating speedily, yet extensive, from the fundamental technology of lung improvement, to the analyses of alternative stem cellphone varieties on hand for regeneration and directly to the appliance of this information base in preliminary scientific trials. during this quantity a stellar workforce of researchers converge, from various angles, to assist in the direction of clarifying the elemental mechanisms of lung fix. those variety from easy innovations of regeneration and lung improvement, the analyses of numerous cellphone kinds that could be inquisitive about lung fix, to methods of constructing complicated lung constructions, together with synthetic and bioartificial lungs. The ebook bargains an perception into fix mechanisms of the diseased lung, the position of particular lung niches and gives info on preliminary medical trials in addition to using stem cells as automobiles for gene remedy. creative technological features of assessing stem phone engraftment of stem telephone bioprocessing also are incorporated during this quantity.

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M. Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs. Transplantation 80(2), 206–212 (2005). 83. E. Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair. Tissue Eng 11(7–8), 1115–1121 (2005). 84. C. Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 33(4), 328–334 (2005). 85. , and Fine, A. Evidence that bone marrow cells do not contribute to the alveolar epithelium.

54. , and Cutz, E. Expression of CFTR and Cl(−) conductances in cells of pulmonary neuroepithelial bodies. Am J Physiol Lung Cell Mol Physiol 281(3), L713–L721 (2001). 55. , and Yeger, H. Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol 35(3), 320–326 (2006). 56. C. and Borok, Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293(3), L525–L534 (2007). 57.

A prototypical rapidly renewing tissue is the intestinal epithelium. Tissues in which the steady state mitotic index is low. Specialised cell types are broadly distributed, long-lived, and a subset of these cells, the facultative progenitor cell, retains the ability to enter the cell cycle. The relative stability of the differentiated cell pool is paralleled by infrequent proliferation of stem and/or transit amplifying cells. The lung is an example of a slowly renewing tissue. Cell that has the capacity for self-renewal and ability to differentiate into mature leukocytes, erythrocytes, and platelets.

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Cell Therapy for Lung Disease by Julia Polak

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