Read e-book online Cardiovascular Disease: Molecular and Cellular Mechanisms, PDF

By James Shepherd, Christopher J. Packard (auth.), Linda L. Gallo (eds.)

ISBN-10: 1468452967

ISBN-13: 9781468452969

ISBN-10: 1468452983

ISBN-13: 9781468452983

The 6th Annual foreign Spring Symposium on overall healthiness Sciences, held in Washington, D. C. , in could 1986, introduced jointly over 650 scientists from 19 international locations to check and replace examine on heart problems. during this quantity, which includes fifty nine chapters, an the world over well-known crew of authors con­ tribute up to date bills of molecular and mobile procedures happening within the vessel wall in atherogenesis and describe methods to the prevention and remedy of atherosclerosis. the quantity is split into six significant sections. sections take care of present points of lipoprotein metabolism. partly I, we're alerted to the influence on li­ poprotein metabolism of structural heterogeneity in the 4 huge lipoprotein periods. recognition then turns to the elements that orchestrate lipoprotein metab­ olism. Apolipoprotein identities, processing, and features are defined, as are the jobs of lipid move proteins in plasma lipoprotein home improvement. Hepatic lipase synthesis and secretion are defined. partly II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations within the LDL receptor that show the features of its a variety of domain names and indicate how knowing the LDL receptor has supplied a rational foundation for its rules. A dialogue of the function of receptors in regulating ldl cholesterol uptake through tissues follows, with emphasis on receptor-ligand interactions. extra pathways for ldl cholesterol supply to cells are explored, as are pathways for ldl cholesterol egress.

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Genet. 73:313-319. Beaumont, J. , Carlson, L. , Cooper, G. , Frederickson, D. , 1970, Classification of hyperlipidaemias and hyperiipoproteinaemias, Bull. WHO 43:891-903. , Olofsson, S. , 1985, Molecular cloning of human apolipoprotein B cDNA, Nucleic Acid Res. 13:8813-8824. , 1984, Addendum: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem. 137:266-267. Knott, T. , Rail, S. , Innerarity, T. , Jacobson, S. , Urdea, M. , Powell, L. , Pease, R.

The amino-terminal amino acid sequence of apo C-IL 1/2 was determined by Edman aegradation using a Beckman Sequence Model 890B, and the resulting phenylthiohydantoin derivates were analyzed by HPLC and mass spectroscopy (Fairwell and Brewer, 1980). 10. , 1972, 1974). 3. 5 x 106 phage plaques with the apo C-I1 cDNA probe. One clone was grown in large scale and analyzed following restriction endonuclease digestion by Southern blot. It contained an 18-kb fragment of human genomic DNA inserted into the BamHI cloning site of Charon 28 and extended approximately 4 kb upstream and 10 kb downstream from the apo C-II gene.

H. S .. Donaldson. Y. H .. and Jackson. , 1984. Degradation of apolipoprotein B-1 00 of human plasma low density lipoprotein by tissue and plasma kallikreins, J. Bioi. Chem. 259:8522-8528. Carlsson. P .. Olofsson, S. 0 .. , Damfors. , Wiklund. 0 .. and Bjursell. G .. 1985. Molecular cloning of human apolipoprotein B cDNA. Nucleic Acids Res. 13:8813-8826. Deeb. S. , Motulsky. A. G .. and Alberts, 1. J .. 1985. Partial cDNA clone for human apolipoprotein B. Proc. Natl. Acad. Sci. A. 82:4983-4986.

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Cardiovascular Disease: Molecular and Cellular Mechanisms, Prevention, and Treatment by James Shepherd, Christopher J. Packard (auth.), Linda L. Gallo (eds.)


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