By Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi
Since its identity through Sir Henry H. Dale a century in the past, histamine has turn into probably the most vital multifunctional biogenic amines within the box of biomedicine. The pharmacological results of histamine are mediated via 4 different types of membrane histamine receptors; H1R, H2R, H3R and H4R, that are all heptahelical G-protein-coupled receptors. it's been identified to play the broadest spectrum of actions in quite a few physiological and pathological stipulations together with phone proliferation, differentiation, hematopoiesis, embryonic improvement, regeneration, wound therapeutic, aminergic neurotransmission and various mind services, secretion of pituitary hormones, rules of gastrointestinal and circulatory features, cardiovascular process, in addition to inflammatory reactions, modulation of the immune reaction, endocrine functionality and homeostasis, and different vital parts.
This booklet is a compendium of the present kingdom of confirmed and investigational literature on Histamine, its receptors and their Agonists and antagonists. It offers a finished review of histamine biology within the box of biochemistry, phone biology, molecular biology, immunology, allergic reaction, neurobiology, pharmacology, microbiology and reproductive biology. the 1st part on Histamine biology and body structure leads into next sections on enzymology, pharmacology, law of the immune method and phone proliferation and position in allergic and different illnesses together with acid peptic illnesses, inflammatory illnesses, autoimmune and melanoma illnesses, anxious process, reproductive capabilities and hematopoiesis. The compilation of chapters within the publication offers the newest advances in histamine examine and bridges the fundamental and medical facets of histamine biology.
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Extra info for Biomedical Aspects of Histamine: Current Perspectives
2). DAO is the main enzyme for the metabolism of ingested histamine. 8 M. Shahid et al. Fig. 2 Summary of the histamine metabolism. (I) Histamine is synthesized by decarboxylation of histidine catalyzed by L-histidine decarboxylase (HDC). (II) Histamine can be metabolized by extracellular oxidative deamination of the primary amino group by diamine oxidase (DAO) or (III) intracellular methylation of the imidazole ring by histamine-N-methyltransferase (HNMT). (IV) Thus, insufficient enzyme activity caused by enzyme deficiency or inhibition may lead to accumulation of histamine.
Tanaka and A. Ichikawa Fig. 1 Post-translational regulation of HDC. HDC is initially translated as the precursor 74-kDa form, which is enzymatically active. The 74-kDa HDC then undergoes proteolytic cleavage to yield the 53-kDa mature form. The post-translational processing was found to be mediated by caspase-9 and was accompanied by enzymatical activation in a mouse mastocytoma cell line. On the other hand, the residual 74-kDa HDC might be degraded through the ubiquitin-proteasome system. The carboxyl-terminal region has a potential to target HDC to the ER, although it remains unknown how the ER targeting occurs.
Ar Aurelio A. F. es Judith Ramos-Jiménez Colegio de Ciencia y Tecnología, Universidad de la Ciudad de México, Av. La Corona No. 320, Col. F. M. jp About the Editors Dr. N. Medical College & Hospital, Aligarh Muslim University, India. He has recently been awarded the Young Scientist Award by the Department of Science & Technology, Ministry of Science & Technology, Govt. of India. , during 2005–2006 to work with Prof. Peter Hawkey’s group on the antibiotics resistance problem. His field of interest and research is confined to mechanism and resistance to beta-lactam antibiotics, with special interest in CTX-M and AmpC β-lactamases, plasmid-mediated drug resistance, and indigenous drugs.
Biomedical Aspects of Histamine: Current Perspectives by Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi