Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen's Asthma and COPD, Second Edition: Basic Mechanisms and PDF

By Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen I. Rennard, Neil C. Thomson

ISBN-10: 0123740010

ISBN-13: 9780123740014

The second one version of bronchial asthma and COPD: uncomplicated Mechanisms and scientific administration maintains to supply a different and authoritative comparability of bronchial asthma and COPD. Written and edited via the world's prime specialists, it is still a finished evaluate of the newest realizing of the fundamental mechanisms of either stipulations, particularly evaluating their etiology, pathogenesis, and coverings.
* every one bankruptcy considers bronchial asthma and COPD in side-by-side distinction and comparability - no longer in isolation - within the context of mechanism, triggers, checks, cures, and scientific management
* offers the newest and so much accomplished understandings of the mechanisms of irritation in either bronchial asthma and COPD
* such a lot broad connection with fundamental literature on either bronchial asthma and COPD in a single source.
* Easy-to-read summaries of the most recent advances along transparent illustrations

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Additional resources for Asthma and COPD, Second Edition: Basic Mechanisms and Clinical Management

Example text

In a cohort of children enrolled in 1964 and reassessed in 2001 for current lung function, smoking status, and respiratory symptoms, a significant linear trend was found between birth weight and FEV1 at age 45–50 years after adjusting for confounders, including smoking [65]. This association was confirmed by a recent meta-analysis [66] of eight studies reporting a pooled increase of 48 ml in FEV1 per 1 kg in birth weight. As modest as this association may appear, these findings support a direct influence of in utero growth on lung function in adulthood.

Oswald H, Phelan PD, Lanigan A, Hibbert M, Bowes G, Olinsky A. Outcome of childhood asthma in mid-adult life. BMJ 309(6947): 95–96, 1994. Natural History 10. Jenkins MA, Hopper JL, Bowes G, Carlin JB, Flander LB, Giles GG. Factors in childhood as predictors of asthma in adult life. BMJ 309(6947): 90–93, 1994. 11. Anderson HR, Pottier AC, Strachan DP. Asthma from birth to age 23: Incidence and relation to prior and concurrent atopic disease. Thorax 47(7): 537–42, 1992. 12. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD.

The main early life determinants of the level of FEV1 in old age were birth weight and history of bronchitis or pneumonia in infancy, and these effects were independent of smoking habit and social class. These data would thus suggest that both intrauterine growth (and presumably lung development) and lower respiratory illnesses during the first years of life exert independent effects on the level of lung function attained late during adult life, and thus may be important determinants of the risk of COPD.

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Asthma and COPD, Second Edition: Basic Mechanisms and Clinical Management by Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen I. Rennard, Neil C. Thomson


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