By Albert Uderzo
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Extra info for Asterix and Son
The former process generates new varieties and the latter one generates new combinatorial realizations of the genetic differences. Nucleotide sequencing reveals the differences between the individuals and make them available for bioinformatical processing. Roughly 107 single nucleotide polymorphisms are known today what means one to ten polymorphic sites per thousand nucleotides. 24 Point Mutation Fig. 5. The asymmetries of the GC, AC/GT, AT, CG, CA/TG and TA replacements. See also the caption of Fig.
Mol. Genet. Genomics 279:53-61 Cox, R & Mirkin, S M (1997) Characteristic enrichment of DNA repeats in different genomes. Proc. Natl. Acad. Sci. USA 94:5237-5242 30 Point Mutation Davydov, E; Goode, D; Sirota, M; Cooper, G; Sidow, A; et al. (2010) Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput. Biol. 6:e1001025 (13pages) Fryxell, K J & Moon W-J (2005) CpG mutation rates in the human genome are highly dependent on local GC content. Mol.
This should not have been surprising given that antibiotic-resistant bacteria and insecticide-resistant insects emerged as a result of natural selection. , one mutation in 10,000 bases, while DNA viruses have a rate of 10–8) and evolve rapidly, thereby allowing genotypes encoding for drug resistance to arise. , 2007). The drug resistance of viruses is relative, rather than absolute. A measure of the degree of resistance can be obtained by determining the IC50. A virus strain is considered to be ‘resistant’ to a drug if it is able to replicate in the body in the presence of a concentration of the drug that inhibits replication of ‘sensitive’ strains.
Asterix and Son by Albert Uderzo