By Edwin H. Flynn, Carl W. Godzeski (auth.), David Gottlieb, Paul D. Shaw (eds.)
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Extra info for Antibiotics: Volume I Mechanism of Action
J. WEINBERGER: Induction and cultivation of staphylococcal L-forms in the presence of methicillin. J. Bacteriol. 83, 1162 (1962). KAGAN, G. : Review of pathogenicity of L-forms. Klin. Med. ) 39,12 (1961).
These cells would then become "persisters" and survive the initial onslaught of penicillin therapy. A period of nonexposure to antibiotic would allow the resting cells time to revitalize themselves and initiate active growth processes, thereby increasing their susceptibility to delayed penicillin treatment. This therapeutic idea is as sound today as it was in 1944. , 1965). The "persister" problem was discussed by McDERMOTT (195 8), but there remain many aspects of chronic and relapsing infections that have defied analysis.
The bactericidal action of penicillin on Staphylococcus pyogenes. Irish J. Med. Sci. 6, 553 (1944a). BIGGER, J. W. : Treatment of staphylococcal infections with penicillin by intermittent sterilization. Lancet 1944IIb, 497. BRAUDE, A. , J. SIEMIENSKI, and I. JAcoBs: Protoplast formation in human urine. Trans. Assoc. Am. Physicians 74, 234 (1961). : Bacterial genetics. Philadelphia: W. B. Saunders Co. 1953. : Cellular products affecting the establishment of bacteria of different virulence. Ann.
Antibiotics: Volume I Mechanism of Action by Edwin H. Flynn, Carl W. Godzeski (auth.), David Gottlieb, Paul D. Shaw (eds.)