By Roger J. Laham, Donald S. Baim
An interdisciplinary panel of pioneers and opinion leaders evaluate the fundamental, preclinical, medical, and developmental pathways to new remedy recommendations, reminiscent of healing angiogenesis and myogenesis. The authors reap the benefits of new organic realizing, novel healing ambitions, a number of to be had and well-studied healing ideas, and the required imaging suggestions to degree results. Their in-depth discussions conceal the identity of latest healing ambitions and pathways, the research of transcriptional elements, grasp swap molecules, cell-based techniques, chemokines, a greater realizing of the results of getting older, endothelial disorder, and hypercholesterolemia in line with angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem remedy, high-risk interventions, improvement pathways, and destiny percentages.
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Additional info for Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)
The transcription factor EPAS-1/hypoxiainducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA 2000;97:8386–8391. 20. Arany Z, Huang LE, Eckner R, et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996;93:12969–12973. 21. Oike Y, Takakura N, Hata A, et al. Mice homozygous for a truncated form of CREBbinding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood 1999;93:2771–2779. 22. Cockman ME, Masson N, Mole DR, et al.
14. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435–439. 15. Carmeliet P, Mackman N, Moons L, et al. Role of tissue factor in embryonic blood vessel development. Nature 1996;383:73–75. 16. Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 1999;209:254–267. 17. Tian H, McKnight SL, Russell DW.
In contrast, the von Hippel–Lindau tumor suppressor protein (pVHL) has been shown to promote proteolysis of HIF-1α through ubiquitylation under normoxic conditions. Defective VHL function is associated with cancers that exhibit dysregulated angiogenesis and upregulation of hypoxia inducible genes (22). The signaling mechanisms by which hypoxia activates HIF-1α are beginning to be elucidated. The catalytic subunit of PI3-kinase, p110, plays a pivotal role in the induction of HIF-1 activity in response to hypoxia (23).
Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology) by Roger J. Laham, Donald S. Baim