Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash PDF

By Trevor M. Penning, J. Mark Petrash

ISBN-10: 0841219702

ISBN-13: 9780841219700

ISBN-10: 0841238464

ISBN-13: 9780841238466

content material: part 1: basic evaluation ; 1. advent and evaluation of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic problems ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the cleansing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO similar cancer causing agents ; five. Competing Roles of Reductases within the cleansing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the lively Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated through the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative rigidity ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic relief vs Adduction with Lysine ; thirteen. using mammalian cellphone traces to enquire the function of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the tension reaction AND mobilephone SIGNALING ; 14. Aldose Reductase and the strain reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory indications ; sixteen. Aldo-Keto Reductases within the rigidity reaction of the Budding Yeast Saccharomyces cerevisiae

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Srivastava, S. K. J. Biol. Chem. 2002, 277, 32063-32070. 40. ; Liu, S. ; Runge, M. ; Bhatnagar, A. Arterioscler Thromb. 2000, 20, 1745-1752. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. Chapter 4 Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids 1 2 2 Sanjay Srivastava , Kota V. Ramana , Satish K. Srivastava , Stanley E. ch004 3 1 Departments of Medicine, Division of Cardiology and Physiology and Biophysics, University of Louisville, Louisville, KY 40202 Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 1 3 2 Oxidation of phospholipids generates products in which unsaturated fatty acids at the sn-2 position are oxidized to short chain aldehydes or epoxides.

Biol. Chem. 2002, 277, 32063-32070. 40. ; Liu, S. ; Runge, M. ; Bhatnagar, A. Arterioscler Thromb. 2000, 20, 1745-1752. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. Chapter 4 Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids 1 2 2 Sanjay Srivastava , Kota V. Ramana , Satish K. Srivastava , Stanley E. ch004 3 1 Departments of Medicine, Division of Cardiology and Physiology and Biophysics, University of Louisville, Louisville, KY 40202 Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 1 3 2 Oxidation of phospholipids generates products in which unsaturated fatty acids at the sn-2 position are oxidized to short chain aldehydes or epoxides.

Dixit, B. ; Balendiran, G. ; Srivastava, S. ; Bhatnagar, A. Biochemistry 2000, 39, 12172-12180. 38. ; Dixit, B. ; Ramana, K. ; Petrash, J. ; Srivastava, S. K. Biochem. J. 2001, 58, 111-118. 39. Vander Jagt, D. ; Hassebrook, R. ; Hunsaker, L. ; Brown, W. M . ; Royer, R. E. Chem Biol Interact. 2001, 130-132, 549-562. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. Chapter 3 Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates 1 1 2 Satish K. Srivastava , Kota V.

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Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash


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