Professor Dr. Frank G. Holz, Professor Dr. Daniel's Age-related macular degeneration PDF

By Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)

ISBN-10: 3662051990

ISBN-13: 9783662051993

ISBN-10: 3662052016

ISBN-13: 9783662052013

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Extra resources for Age-related macular degeneration

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The various phenotypes of AMD appear to represent common downstream pathogenetic pathways with heterogeneous underlying etiolog ies on a molecular and cel lular level i nthe retina/RPE/choroid complex. It is not yet known at what anatomic layer primary defects leading to the sight-threatening lesions of AMD are located. However, there is increasing evidence to suggest that gradual impairment of essential RPE cel l functions plays an important role. This hypothesis is further supported by the fact that the RPE cell layer is involved in all clinical AMD phenotypes, particularly the formation of drusen as an early hallmark of the disease.

2000) Oxidative damage and protection of the RPE. Prog Retin Eye Res 19:205-221 Chang Bet al. (1995) Choroidal neovascularization in second eyes of patients with unilateral exudative age-related macular degeneration. Ophthalmology 102:13801386 Cho E et al. (2000) Prospective study of alcohol consumption and the risk of age-related macular degeneration. Arch Ophthalmol 118:681-688 Cho E et al. (2001) Prospective study of zinc intake and the risk of age-related macular degeneration. Ann Epidemiol 11:328-336 Christen WG et al.

However, clear evidence for the pathophysiological role of free radicals under normal conditions is lacking, since most observations have been obtained in experimental studies in a non-physiological environment. In addition, the RPE is rich in antioxidants and possesses a high capacity for scavenging free radicals. Nevertheless, recent clinical results from the Age-Related Eye Disease Study (AREDS) demonstrated a prophylactic effect with regard to the conversion from early to late-stage AMD after intake of high doses of vitamin C, vitamin E, beta-carotene and zinc (see Chap.

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Age-related macular degeneration by Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)


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