By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual loss of life toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of recent medications, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and educating within the box of TB. It comprises a hundred colour photos and illustrations that deliver readability to the knowledge awarded. The atlas takes the weird process of masking a number of species histopathology, arguably the 1st and particularly almost certainly the single source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal types. The editors have compiled info that is helping TB scientists to tell apart among the positive factors of all significant animal types on hand and to take advantage of them with their strengths and boundaries in brain. The booklet offers tips for choosing the easiest animal model(s) to reply to particular questions and to check the efficacy of drug applicants.
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Additional info for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
Expense of maintenance, cost of purchase, BSL-3 housing, and availability of immunological reagents are more problematic for these two species, even more so for the rabbit. Although reagent development has progressed in the past few years, reagents for flow cytometry studies, cytokine measurement, and immunohistochemistry remain scarce, with limited hope for significant improvement due to the small market. The Nonhuman Primate There are many logistical and practical hurdles associated with the use of nonhuman primates: cost of breeding, expense and difficulty in maintaining animals in BSL-3 facilities, and reluctance of bioethical and animal welfare committees to approve monkey studies.
Chapter 2 Tuberculosis Biology and Drug Discovery Thomas Dick Contents Disease Manifestations and Treatment A Largely Unmet Medical Need The Challenge of TB Drug Discovery An Atlas for TB Drug Discovery References 14 15 16 17 17 M yc obact er ium t uber cu l o sis (MTB) is the causative agent of tuberculosis (TB). First discovered in 1882 by Robert Koch, the tubercle bacillus has an unusual waxy coat primarily made up of mycolic acids. Because of its unique cell wall structure, the organism does not retain the usual bacteriological stains and thus is neither a Gram positive nor a Gram negative.
And Dick, T. 2009. TB drug discovery: Issues, gaps and the way forward. In Antiparasitic and antibacterial drug discovery: From molecular targets to drug candidates, ed. P. Selzer, 415–440. Weinheim: Wiley-VCH. D. 2009. The global burden of tuberculosis— Combating drug resistance in difficult times. N Engl J Med, 360, 2393–2395. Nathan, C. 2009. Taming tuberculosis: A challenge for science and society. Cell Host Microbe, 5, 220–224. S. 2008. Drugs versus bugs: In pursuit of the persistent predator Mycobacterium tuberculosis.
A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis by Franz Joel Leong, Veronique Dartois, Thomas Dick